The EAWAG-BBD Nicotine Pathway

• 2,6-Dihydroxypseudooxynicotine -----> 2,6-Dihydroxy-N-methylmysosmine (reacID# r0481)
• 2,6-Dihydroxypseudooxynicotine -----> 2,6-Dihydroxypyridine + 4-Methylaminobutyrate (reacID# r0482)
• 2,5-Dihydroxypyridine -----> N-Formylmaleamate (reacID# r1443)
• 2,6-Dihydroxypyridine -----> 2,3,6-Trihydroxypyridine (reacID# r0479)
• N-Formylmaleamate -----> Formate + Maleamate (reacID# r1721)
• 6-Hydroxy-3-succinoylpyridine -----> 2,5-Dihydroxypyridine + Succinic semialdehyde (reacID# r1442)
• (R)-6-Hydroxynicotine -----> 6-Hydroxypseudooxynicotine (reacID# r0478)
• (S)-6-Hydroxynicotine -----> 6-Hydroxypseudooxynicotine (reacID# r0477)
• 6-Hydroxypseudooxynicotine -----> 2,6-Dihydroxypseudooxynicotine (reacID# r0480)
• 6-Hydroxypseudooxynicotine -----> 6-Hydroxy-3-succinoylpyridine (reacID# r1441)
• 4-Methylaminobutyrate -----> 4-aminobutanoate + Formaldehyde (reacID# r1827)
• 4-Methylaminobutyrate -----> Carbon Dioxide (reacID# r0503)
• 4-Methylaminobutyrate -----> Methylamine + Succinic semialdehyde (reacID# r1828)
• (RS)-Nicotine -----> (R)-6-Hydroxynicotine (reacID# r0978)
• (RS)-Nicotine -----> (S)-6-Hydroxynicotine (reacID# r0979)
• Succinic semialdehyde -----> Succinate (reacID# r0371)
• 2,3,6-Trihydroxypyridine -----> Maleamate (reacID# r0483)

• 4-aminobutanoate [56-12-2] (compID# c1588)
• Carbon Dioxide [124-38-9] (compID# c0131)
• 2,6-Dihydroxy-N-methylmysosmine (compID# c0477)
• 2,6-Dihydroxypseudooxynicotine (compID# c0469)
• 2,5-Dihydroxypyridine [5154-01-8] (compID# c1250)
• 2,6-Dihydroxypyridine [626-06-2] (compID# c0473)
• Formaldehyde [50-00-0] (compID# c0122)
• Formate [64-18-6] (compID# c0106)
• N-Formylmaleamate (compID# c1484)
• 6-Hydroxy-3-succinoylpyridine (compID# c1249)
• (R)-6-Hydroxynicotine (compID# c0470)
• (S)-6-Hydroxynicotine (compID# c0471)
• 6-Hydroxypseudooxynicotine [7424-35-3] (compID# c0472)
• Maleamate [557-24-4] (compID# c0476)
• Methylamine [74-89-5] (compID# c0137)
• 4-Methylaminobutyrate [1119-48-8] (compID# c0474)
• (RS)-Nicotine [54-11-5] (compID# c0468)
• Succinate [110-15-6] (compID# c0312)
• Succinic semialdehyde [692-29-5] (compID# c0311)
• 2,3,6-Trihydroxypyridine [39954-19-3] (compID# c0475)

• EC 1.2.1.16 succinic semialdehyde dehydrogenase (enzymeID# e0020)
• EC 1.5.-.- 6-hydroxypseudooxynicotine dehydrogenase (enzymeID# e0912)
• EC 1.5.3.5 6-hydroxy-D-nicotine oxidase (enzymeID# e0338)
• EC 1.5.3.6 6-hydroxy-L-nicotine oxidase (enzymeID# e0339)
• EC 1.5.3.19 4-methylaminobutanoate oxidase (enzymeID# e1235)
• EC 1.5.3.21 4-methylaminobutanoate oxidase (methylamine-forming) (enzymeID# e1236)
• EC 1.5.99.4 nicotine dehydrogenase (enzymeID# e0337)
• EC 1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase (enzymeID# e0342)
• EC 1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase (enzymeID# e0911)
• EC 1.14.13.10 2,6-dihydroxypyridine 3-hydroxylase (enzymeID# e0340)
• EC 3.5.1.106 N-formylmaleamate deformylase (enzymeID# e1149)
• EC 3.7.1.- 6-hydroxy-3-succinoylpyridine hydrolase (enzymeID# e0913)
• EC 3.7.1.9 2,6-dihydroxypseudooxynicotine hydrolase (enzymeID# e0625)

Page Author(s): Ben Vickers, Meaghan Fitzgerald, Sean Anderson, Lynda Ellis and Michael Turnbull
September 28, 1998 12:04:07 PM CDT Contact Us

This is the EAWAG-BBD compounds and reactions page for the Nicotine Pathway.
It was generated on June 20, 2025 at 7:27:50 PM CDT.

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